Contact numbers and address

Reproductive Medicine Clinic

Address: 82290, Level J 8 (Opposite Theatre)
Tel: 012 354 2540/5337
Fax: 012 354 2557
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Reproductive Biology Laboratory (RBL)

Address: 72351, Level 7
Tel: 012 354 2208
Fax: 012 329 6258
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  • Consultant: Dr A De Bruin
  • Consultant: Dr M Trouw
  • Consultant: Dr J Biko
  • Consultant: Dr H Kruger
  • Consultant: Dr Z Nene
  • Medical Officer: Dr K Singh
  • Registrar (Department of Obstetrics and Gynaecology, University of Pretoria)
  • Clinic nurses
  • Clinic Secretary

Reproductive Biology Laboratory (RBL)

  • Prof. C Huyser (Head of the Laboratory)
  • Embryologists (scientists and technologists)
  • Laboratory Secretary
  • Mr G Boshoff
  • Ms S Maharaj

Who do we see?

  • Infertile couples (see "Referral for Infertility")

  • Couples where either partner has a history of fertility related problems

  • Partner has a low sperm count or abnormal semen parametersEndocrine problems associated with infertility

  • HIV positive couples who wish to undergo risk reduction methods of Assisted Reproductive Techniques (ART). Certain criteria must be met before ART can be offered.

  • All patients must have a referral letter with copies of the required recent results. (Please see "Basic Workup")

  • Patients must follow the appropriate referral system from the Primary Health Care Facility or Medical Practitioner or Secondary Health Care Facility or Gynaecologist.

  • Our Unit encourages openness of all medical conditions between both partners prior to the initial consultation in order for the unit to provide the couple with the appropriate and optimal care.

  • Both partners are seen together at the initial and follow up appointments.

What we do

  • Infertility work-up
  • Laparoscopic surgery where indicated
  • Assisted Reproduction Technology (ART) procedures:
    • Intra-uterine insemination (IUI)
    • In-vitro fertilization (IVF)
    • Intra-Cytoplasmic sperm injection (ICSI)
    • Intra-uterine insemination with donor sperm
    • In-vitro fertilization with donor sperm
    • In-vitro fertilization or ICSI with an oocyte (egg) donor
    • In-vitro fertilization or ICSI with a surrogate mother.

Please note: patients will need to arrange their own oocyte donor and surrogate mother.


  • All patients are seen by appointment only.
  • Patients must allow sufficient time for parking, registration and opening of the unit file.
  • Patients in the Semen Decontamination Programme: Appointments on a Thursday.
  • Patients in Assisted Reproductive Techniques (ART) Programme must be at the Unit at 07:00 and no later than 07:30.
  • Patients already in the ART programme or undergoing procedures may take precedence over New and Follow up patients.
  • Every effort will be made to adhere to scheduled times.

Clinic times

  • Monday to Thursday 07:00 – 16:00 and
  • Fridays 07:00 – 13:00

Protocols for referral to the Reproductive and Endocrine Unit

Endocrine Clinic


  • All patients with Primary Amenorrhoea
  • Secondary amenorrhoea, after a failed progesterone challenge test
  • With abnormal Thyroid Function Tests
  • With Hyperprolactinaemia
  • Ambiguous genitalia
  • Chromosomal abnormalities e.g. Turner’s syndrome
  • Polycystic ovarian syndrome (PCOS)
  • Hyperandrogenism
  • Premature Ovarian Dysfunction

Hysteroscopy Clinic

  • Post-Menopausal Bleeding
  • Recurrent pregnancy losses
  • Uterine abnormalities
  • Polyps
  • Sub mucous myomas
  • Removal of foreign body - Lost intrauterine contraceptive device (IUCD)
  • Secondary amenorrhoea with failed progesterone challenge test
  • Abnormal uterine bleeding – not responding to hormone therapy
  • Sterilisation with ESSURE®\
  • Tubal occlusion with ESSURE® for hydrosalpinges in women undergoing IVF/ICSI

Referral for Infertility

< 35 years

with 1 year of history of inability to fall pregnant after adequate, unprotected intercourse

>35 years

with 6 months history of inability to fall pregnant after adequate, unprotected intercourse

Refer immediately in women

  • 40 years old (not older than 41 years old )
  • previous ovarian surgery
  • exposure to cytotoxic drugs
  • autoimmune disease
  • strong family history of premature ovarian failure/early menopause
  • suspected endometriosis
  • known or suspected uterine/tubal disease/tubal surgery
  • all patients requesting tubal re-anastomosis (reversal of sterilisation)

Cut-off age for referral is 40 years old.

  • Women older than 40 may opt for IVF with an oocyte (egg) donor.
  • Please see "Criteria for Suitable Egg Donor"
  • The age cut-off for recipients is 50 years old.
  • Please see "Criteria for Recipients"

BMI < 19 and > 30 kg/m2

  • Poor success rate
  • Refer patient to dietician / weight loss programmes
  • BMI to be between 19 – 30 before commencing ART

Age < 40

Offer 3 Cycles only (if no history of other IVF treatment )

Age > 40 < 41

  • Offer 1 Cycle only ( if no previous History of other IVF treatment and if no evidence of low ovarian reserve)
  • Patient to be advised on implications of Advanced Maternal Age

Basic Workup


FSH, LH, Estradiol (Day 2 menstruation)

Thyroid Function Test (TFT)

  • In women with Thyroid disease
  • In women with ovulatory disorders
  • galactorrhoea


  • in women with ovulatory disorders
  • galactorrhoea
  • Symptoms and signs suggestive of pituitary tumours


Rubella IgG

Syphilis (RPR)

Hepatitis B & C

Pap smear



Syphilis (RPR)

Hepatitis B & C

Semen Analysis (to be done at SBAH)

Test for tubal patency (where possible)

Hysterosalpingogram (HSG): if no history of Pelvic Inflammatory Disease or endometriosis


Laparoscopy and chromopertubation

Requirements for the first visit

  • Two (2) ID photos each of partner
  • Copies of ID / Passport documents of both partners
  • Proof of income (payslip) for both partners. If either or both partners are unemployed a 3 months bank statement or an affidavit from the SAPS is required
  • Proof of residence (e.g. Rates account statement, Rental agreement)
  • Referral letter and copies of previous results (mandatory)
  • Please confirm your appointment (Tel: 012 354 2540) at least one (1) week beforehand
  • Consultation fees charged as determined by income or as per tariff rates.
  • Accounts of the investigations performed will be forwarded to the person responsible for the payment. Private and Foreign patients will pay in cash on the day of the tests.
  • A semen analysis will be requested on the day of your appointment. A period of three (3) days abstinence is required. Results can take up to 1 - 2 weeks.
  • Foreign Patients:
    • Foreigners need to follow the admission criteria of the hospital.
    • Foreigners must follow-up and obtain clearance from the hospital’s Finance Department.
    • All legal documents must be in order and valid for at least 6 months from time of first appointment.

First Visit

  • Both partners must be present for the first consultation
  • A full history is taken from both partners
  • Systemic as well as the gynaecological examination is performed
  • A pelvic ultrasound is done
  • Possible problems are identified and solutions offered
  • The basic facts of Assisted Reproductive Techniques (ART) procedures and costs are explained
  • A semen sample will be analysed by our staff at our Reproductive Biology Laboratory (RBL). This is important as our laboratory will be handling the semen and the embryos.
  • Patients or couples may be referred to the Dietician, General Practitioner, Medical Specialist, Lawyer, Psychologist or social worker for further consultation and evaluation. The ART procedure of choice can only be discussed once all the reports become available.
  • A multi-disciplinary team approach is adopted for holistic care

Follow-up Visit

  • Should be scheduled by the couple within 2 weeks of initial appointment. All results of investigations performed must be in the file. Follow up visits is subject to availability of appointments.
  • Results are discussed.
  • The relevant ART procedure will be discussed in detail with the couple.
  • The procedure, success rates, approximate costs, risks, complications and cycle dates will be explained by the doctor and the nurse i.e. Rest of Team
  • The couple is given the opportunity to ask questions
  • The couple signs the Unit’s informed consent form.
  • Some patients may be required to repeat tests or consult with a Dietician, General Practitioner, Specialist, Lawyer, Social worker or the Psychologist before "Rest of Team" can be performed.


  • Further infertility work-up if indicated (ultrasound examination / semen decontamination etc.)
  • Office Hysteroscopy where indicated
  • Laparoscopic and /or hysteroscopic surgery where indicated
  • Assisted Reproductive Techniques (ART) procedures:
    • Intra-uterine insemination (IUI)
    • In-vitro fertilization (IVF)
    • Intra-cytoplasmic sperm injection (ICSI)
    • Intra-uterine insemination with donor sperm
    • IVF with donor sperm
    • or ICSI with a known oocyte (egg) donor
    • IVF or ICSI with a surrogate mother.
    • Semen Decontamination in HIV positive men

 Please download more details on the above Procedures